4-Chloro-3',4'-dimethylbutyrophenone → N-(6-{1-[4-(3,4-Dimethylphenyl)-4-oxobutyl]-4-piperidinyl}-2-pyridinyl)-2-methylpropanamide

HRID 1832419Notes

Reaction equation

HRID 1832419 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([CH3:14])[CH:8]=1)=[O:6].[CH3:15][CH:16]([CH3:32])[C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[N:21]=1)=[O:18]>>[CH3:14][C:9]1[CH:8]=[C:7]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][N:29]2[CH2:30][CH2:31][CH:26]([C:22]3[N:21]=[C:20]([NH:19][C:17](=[O:18])[CH:16]([CH3:15])[CH3:32])[CH:25]=[CH:24][CH:23]=3)[CH2:27][CH2:28]2)[CH:12]=[CH:11][C:10]=1[CH3:13]

Participants

3

Reactant 2

HCID 987424-Chloro-3',4'-dimethylbutyrophenoneHCID 22048748Propanamide, 2-methyl-N-[6-(4-piperidinyl)-2-pyridinyl]-

Product 1

HCID 22049414N-(6-{1-[4-(3,4-Dimethylphenyl)-4-oxobutyl]-4-piperidinyl}-2-pyridinyl)-2-methylpropanamide

Procedure

Prepared by Procedure G and Scheme AI using 4-chloro-1-(3,4-dimethylphenyl)-1-butanone and 2-methyl-N-[6-(4-piperidinyl)-2-pyridinyl]propanamide: ESMS m/e: 422.1 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme AI

Sources & evidence

ORD record
ord-dce31259a3f149e690264f60fcff0fab
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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