2-methyl-N-[2-methyl-5-(4-piperidinyl)phenyl]propanamide → N-(5-{1-[(3S)-3-(3-Acetylphenoxy)-3-phenylpropyl]-4-piperidinyl}-2-methylphenyl)-2-methylpropanamide

HRID 1832430Notes

Reaction equation

HRID 1832430 reaction equation
Cl[CH2:2][CH2:3][C@H:4]([O:11][C:12]1[CH:13]=[C:14]([C:18](=[O:20])[CH3:19])[CH:15]=[CH:16][CH:17]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:21][CH:22]([CH3:39])[C:23]([NH:25][C:26]1[CH:31]=[C:30]([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:29]=[CH:28][C:27]=1[CH3:38])=[O:24]>>[C:18]([C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[O:11][C@H:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][CH2:2][N:35]1[CH2:36][CH2:37][CH:32]([C:30]2[CH:29]=[CH:28][C:27]([CH3:38])=[C:26]([NH:25][C:23](=[O:24])[CH:22]([CH3:21])[CH3:39])[CH:31]=2)[CH2:33][CH2:34]1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 220486082-methyl-N-[2-methyl-5-(4-piperidinyl)phenyl]propanamideHCID 695236581-(3-{[(1S)-3-chloro-1-phenylpropyl]oxy}phenyl)ethanone

Product 1

HCID 60078714N-(5-{1-[(3S)-3-(3-Acetylphenoxy)-3-phenylpropyl]-4-piperidinyl}-2-methylphenyl)-2-methylpropanamide

Procedure

Prepared by Procedure G and Scheme AI using 1-(3-{[(1S)-3-chloro-1-phenylpropyl]oxy}phenyl)ethanone and 2-methyl-N-[2-methyl-5-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 512.9 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme AI

Sources & evidence

ORD record
ord-9f2ca647207749a79d30cdd7b69394b5
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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