1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) → N-(3-{1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide

HRID 1832434Notes

Reaction equation

HRID 1832434 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH:5]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1.[CH3:20][CH:21]([CH3:38])[C:22]([NH:24][C:25]1[CH:30]=[CH:29][C:28]([CH3:31])=[C:27]([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:26]=1)=[O:23]>>[F:12][C:9]1[CH:10]=[CH:11][C:6]([CH:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:4][CH2:3][CH2:2][N:35]2[CH2:36][CH2:37][CH:32]([C:27]3[CH:26]=[C:25]([NH:24][C:22](=[O:23])[CH:21]([CH3:20])[CH3:38])[CH:30]=[CH:29][C:28]=3[CH3:31])[CH2:33][CH2:34]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 768201,1'-(4-Chlorobutylidene)bis(4-fluorobenzene)HCID 167572542-Methyl-N-[4-methyl-3-(4-piperidinyl)phenyl]propanamide

Product 1

HCID 22048974N-(3-{1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide

Procedure

Prepared by Procedure G and Scheme AI using 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene and 2-methyl-N-[4-methyl-3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 505.0 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme AI

Sources & evidence

ORD record
ord-95a46e9aa7f046638955eb641b32ab9d
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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