(R)-2-Chloro-1-phenylethanol → HCID 69523630, compound

HRID 1832443Notes

Reaction equation

HRID 1832443 reaction equation
Cl[CH2:2][C@@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[OH:4].[CH3:11][CH:12]([CH3:28])[C:13]([NH:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:17]=1)=[O:14].OC[C@@H](C)CN1CCC(C2C=C(NC(=O)C(C)C)C=CC=2)CC1.ClC[C@H](C)CO>>[OH:4][C@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:2][N:25]1[CH2:26][CH2:27][CH:22]([C:18]2[CH:17]=[C:16]([NH:15][C:13](=[O:14])[CH:12]([CH3:11])[CH3:28])[CH:21]=[CH:20][CH:19]=2)[CH2:23][CH2:24]1

Participants

5

Reactant 4

HCID 7018857(R)-2-Chloro-1-phenylethanolHCID 10080353(2R)-3-chloro-2-methyl-1-propanolHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide2×HCID 69658006HCID 69658006, compound

Product 1

HCID 69523630HCID 69523630, compound

Procedure

Prepared by Procedure G and Scheme B1 using (1R)-2-chloro-1-phenylethanol and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 367.2 (M+H)+. N-(3-{1-[(2S)-3-HYDROXY-2-METHYLPROPYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE: Prepared by Procedure G and Scheme B1 using (2R)-3-chloro-2-methyl-1-propanol and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 319.2 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme B1

Sources & evidence

ORD record
ord-d623d25ec1d345c8ba0ad9f65a90a04e
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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