4-Fluorophenylacetyl chloride → 4-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}-1-phenylbutyl (4-fluorophenyl)acetate

Beteiligte Stoffe

Reaktionsschritte

Prepared by Procedure Q1 and Scheme C2 (TEA) using N-{3-[1-(4-hydroxy-4-phenylbutyl)-4-piperidinyl]phenyl}-2-methylpropanamide and (4-fluorophenyl)acetyl chloride: 1H NMR (400 MHz, CDCl3) δ 7.45 (s, 1H), 7.34–7.19 (m, 8H) 7.11 (m, 1H), 6.98 (m, 3H), 5.75 (t, 1H, J=6.8 Hz) 3.61 (s, 2H), 2.92 (d, 2H, J=8.1 Hz), 2.48 (m, 2H) 2.31 (m, 2H), 1.99–1.84 (m, 4H), 1.84–1.67 (m, 5H) 1.55–1.35 (m, 2H), 1.25 (d, 6H, J=6.9 Hz); ESMS m/e: 531.1 (M+H)+.

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