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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1832449Generated: October 25, 2026

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride → 3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}propyl 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxylate

https://huagongshe.com/reaction/1832449

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chlorideHCID 2736581—
ReactantN-{3-[1-(3-Hydroxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamideHCID 22048877—
Product3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}propyl 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxylateHCID 22049124—

Reaction Steps

Prepared by Procedure Q1 and Scheme C2 (TEA) using N-{3-[1-(3-hydroxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride: ESMS m/e: 542.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07067534B1
Source datasetuspto-grants-2006_06
ORD IDord-9d2c83cfeadd4509bcc2edd2342525f9
Source noteuspto-grants-2006_06