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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1832455Generated: October 26, 2026

5-Methyl-3-phenylisoxazole-4-carbonyl chloride → 3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}propyl 5-methyl-3-phenyl-4-isoxazolecarboxylate

https://huagongshe.com/reaction/1832455

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Methyl-3-phenylisoxazole-4-carbonyl chlorideHCID 85624—
ReactantN-{3-[1-(3-Hydroxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamideHCID 22048877—
Product3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}propyl 5-methyl-3-phenyl-4-isoxazolecarboxylateHCID 22049021—

Reaction Steps

Prepared by Procedure Q1 and Scheme C2 (TEA) using N-{3-[1-(3-hydroxypropyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 5-methyl-3-phenyl-4-isoxazolecarbonyl chloride: ESMS m/e: 490.3 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07067534B1
Source datasetuspto-grants-2006_06
ORD IDord-8da1f0bb240746c1ac878d6377e166ee
Source noteuspto-grants-2006_06