4-Chloro-1,3-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carbonyl Chloride → 4-Chloro-N-((1S)-3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}-1-phenylpropyl)-1,3-dimethyl-1H-pyrazolo[3,4-B]pyridine-5-carboxamide

HRID 1832477Notes

Reaction equation

HRID 1832477 reaction equation
[NH2:1][C@H:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1.[Cl:29][C:30]1[C:35]([C:36](Cl)=[O:37])=[CH:34][N:33]=[C:32]2[N:39]([CH3:43])[N:40]=[C:41]([CH3:42])[C:31]=12>>[Cl:29][C:30]1[C:35]([C:36]([NH:1][C@H:2]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:3][CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:12]=3)[CH2:7][CH2:6]2)=[O:37])=[CH:34][N:33]=[C:32]2[N:39]([CH3:43])[N:40]=[C:41]([CH3:42])[C:31]=12

Participants

3

Reactant 2

HCID 27357324-Chloro-1,3-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carbonyl ChlorideHCID 69523474N-(3-(1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl)phenyl)-2-methylpropanamide

Product 1

HCID 586513194-Chloro-N-((1S)-3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}-1-phenylpropyl)-1,3-dimethyl-1H-pyrazolo[3,4-B]pyridine-5-carboxamide

Procedure

Prepared by Procedure Q1 and Scheme AC using N-(3-{1-((3S)-3-amino-3-phenylpropyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 4-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride: ESMS m/e: 587.3 (M+H)+.

Workup

  1. customPrepared by Procedure Q1 and Scheme AC

Sources & evidence

ORD record
ord-261d294431c24ec99a8a798c14458c7e
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

Loading…