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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1832486Generated: October 26, 2026

1-(4-Nitrophenyl)-5-(trifluoromethyl)pyrazole-4-carbonyl chloride → N-((1S)-3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl)-1-phenylpropyl)-1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

https://huagongshe.com/reaction/1832486

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Nitrophenyl)-5-(trifluoromethyl)pyrazole-4-carbonyl chlorideHCID 2775746—
ReactantN-(3-(1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl)phenyl)-2-methylpropanamideHCID 69523474—
ProductN-((1S)-3-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl)-1-phenylpropyl)-1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamideHCID 58651320—

Reaction Steps

Prepared by Procedure Q1 and Scheme AC using N-(3-{1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride: ESMS m/e: 663.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07067534B1
Source datasetuspto-grants-2006_06
ORD IDord-89e2f635d64f4aada1ba55aacbac6206
Source noteuspto-grants-2006_06