1-[3-(3-Chloropropoxy)phenyl]ethanone → N-(3-{1-[3-(3-Acetylphenoxy)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 1832540Notes

Reaction equation

HRID 1832540 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:14])[CH3:13])[CH:9]=[CH:10][CH:11]=1.[CH3:15][CH:16]([CH3:32])[C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:21]=1)=[O:18]>>[C:12]([C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=1)[O:5][CH2:4][CH2:3][CH2:2][N:29]1[CH2:30][CH2:31][CH:26]([C:22]2[CH:21]=[C:20]([NH:19][C:17](=[O:18])[CH:16]([CH3:15])[CH3:32])[CH:25]=[CH:24][CH:23]=2)[CH2:27][CH2:28]1)(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 143487521-[3-(3-Chloropropoxy)phenyl]ethanoneHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22049155N-(3-{1-[3-(3-Acetylphenoxy)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure G and Scheme B1 using 1-[3-(3-chloropropoxy)phenyl]ethanone and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 423.2 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme B1

Sources & evidence

ORD record
ord-1dc9654e71654d6191bb1d5a5d0e5bc8
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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