2-methyl-N-[3-(4-piperidyl)phenyl]propanamide → N-(3-{1-[3-(3,4-Dimethylphenoxy)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 1832548Notes

Reaction equation

HRID 1832548 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([CH3:13])[CH:7]=1.[CH3:14][CH:15]([CH3:31])[C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:20]=1)=[O:17]>>[CH3:13][C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][C:9]=1[CH3:12])[O:5][CH2:4][CH2:3][CH2:2][N:28]1[CH2:29][CH2:30][CH:25]([C:21]2[CH:20]=[C:19]([NH:18][C:16](=[O:17])[CH:15]([CH3:14])[CH3:31])[CH:24]=[CH:23][CH:22]=2)[CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamideHCID 167880053-Chloropropyl 3,4-dimethylphenyl ether

Product 1

HCID 22049618N-(3-{1-[3-(3,4-Dimethylphenoxy)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure G and Scheme B1 using 4-(3-chloropropoxy)-1,2-dimethylbenzene and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 409.2 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme B1

Sources & evidence

ORD record
ord-d743b1a9cf2b405e9a9726718a286d4f
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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