4-(Trifluoromethoxy)phenylhydrazine hydrochloride → 2-Methyl-N-[3-(1-{3-[2-phenyl-5-(trifluoromethoxy)-1H-indol-3-YL]propyl}-4-piperidinyl)phenyl]propanamide

HRID 1832587Notes

Reaction equation

HRID 1832587 reaction equation
[CH3:1][CH:2]([CH3:30])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22](=O)[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4].Cl.[F:32][C:33]([F:44])([F:43])[O:34][C:35]1[CH:40]=[CH:39][C:38]([NH:41]N)=[CH:37][CH:36]=1>>[CH3:1][CH:2]([CH3:30])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][CH2:20][C:21]3[C:39]4[C:38](=[CH:37][CH:36]=[C:35]([O:34][C:33]([F:44])([F:43])[F:32])[CH:40]=4)[NH:41][C:22]=3[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:16][CH2:17]2)[CH:7]=1)=[O:4]

Participants

3

Reactant 2

HCID 27773284-(Trifluoromethoxy)phenylhydrazine hydrochlorideHCID 220493932-methyl-N-(3-[1-(5-oxo-5-phenylpentyl)-4-piperidinyl]phenyl}propanamide

Product 1

HCID 220490032-Methyl-N-[3-(1-{3-[2-phenyl-5-(trifluoromethoxy)-1H-indol-3-YL]propyl}-4-piperidinyl)phenyl]propanamide

Procedure

Prepared by Procedure E and Scheme M using 2-methyl-N-{3-[1-(5-oxo-5-phenylpentyl)-4-piperidinyl]phenyl}propanamide and 1-[4-(trifluoromethoxy)phenyl]hydrazine hydrochloride: ESMS m/e: 564.2 (M+H)+.

Workup

  1. customPrepared by Procedure E and Scheme M

Sources & evidence

ORD record
ord-86810f75f94d4c3aba19891fc61f8f2f
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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