Propionamide → N-(3-{1-[3-(7-Methoxy-2-phenyl-1H-indol-3-YL)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 1832600Notes

Reaction equation

HRID 1832600 reaction equation
[CH3:1][CH:2]([CH3:30])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22](=O)[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4].C(N)(=O)CC.Cl.[CH3:37][O:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[NH:45]N>>[CH3:37][O:38][C:39]1[CH:44]=[CH:43][CH:42]=[C:41]2[C:40]=1[NH:45][C:22]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[C:21]2[CH2:20][CH2:19][CH2:18][N:15]1[CH2:16][CH2:17][CH:12]([C:8]2[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH:2]([CH3:1])[CH3:30])[CH:11]=[CH:10][CH:9]=2)[CH2:13][CH2:14]1

Participants

4

Reactant 3

HCID 6578PropionamideHCID 28494452-Methoxyphenylhydrazine HydrochlorideHCID 220493932-methyl-N-(3-[1-(5-oxo-5-phenylpentyl)-4-piperidinyl]phenyl}propanamide

Product 1

HCID 22049599N-(3-{1-[3-(7-Methoxy-2-phenyl-1H-indol-3-YL)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure E and Scheme M using 2-methyl-N-{3-[1-(5-oxo-5-phenylpentyl)-4-piperidinyl]phenyl}propanamide and 1-5-phenylpentyl)-4-piperidinyl]phenyl}propanamide and 1-(2-methoxyphenyl)hydrazine hydrochloride: ESMS m/e: 510.2 (M+H)+.

Workup

  1. customPrepared by Procedure E and Scheme M

Sources & evidence

ORD record
ord-46792d718eb24856a45ade0f0f7808d5
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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