Hydrazine, 1,1-diphenyl-, hydrochloride (1:1) → 2-Methyl-N-(3-{1-[3-(1-phenyl-1H-indol-3-YL)propyl]-4-piperidinyl}phenyl)propanamide

HRID 1832604Notes

Reaction equation

HRID 1832604 reaction equation
O1CCO[CH:2]1[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([C:16]2[CH:17]=[C:18]([NH:22][C:23](=[O:27])[CH:24]([CH3:26])[CH3:25])[CH:19]=[CH:20][CH:21]=2)[CH2:12][CH2:11]1.Cl.[C:29]1([N:35]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)N)[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH3:25][CH:24]([CH3:26])[C:23]([NH:22][C:18]1[CH:19]=[CH:20][CH:21]=[C:16]([CH:13]2[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][CH2:7][C:6]3[C:30]4[C:29](=[CH:34][CH:33]=[CH:32][CH:31]=4)[N:35]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)[CH:2]=3)[CH2:15][CH2:14]2)[CH:17]=1)=[O:27]

Participants

3

Reactant 2

HCID 10738Hydrazine, 1,1-diphenyl-, hydrochloride (1:1)HCID 22048802N-(3-{1-[4-(1,3-dioxolan-2-yl)butyl]4-piperidinyl}phenyl)-2-methylpropanamide

Product 1

HCID 220491032-Methyl-N-(3-{1-[3-(1-phenyl-1H-indol-3-YL)propyl]-4-piperidinyl}phenyl)propanamide

Procedure

Prepared by Procedure H and Scheme S using N-(3-{1-[4-(1,3-dioxolan-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 1,1-diphenylhydrazine hydrochloride: ESMS m/e: 480.2 (M+H)+.

Workup

  1. customPrepared by Procedure H and Scheme S

Sources & evidence

ORD record
ord-3520d5acfb05450bb434889fd9b5fe01
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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