5-Chloro-1-(4-fluorophenyl)-1-oxopentane → N-(3-{1-[5-(4-Fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)propanamide

HRID 1832694Notes

Reaction equation

HRID 1832694 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)=[O:7].[NH:15]1[CH2:20][CH2:19][CH:18]([C:21]2[CH:22]=[C:23]([NH:27][C:28](=[O:31])[CH2:29][CH3:30])[CH:24]=[CH:25][CH:26]=2)[CH2:17][CH2:16]1>>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:6](=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2][N:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:22]=[C:23]([NH:27][C:28](=[O:31])[CH2:29][CH3:30])[CH:24]=[CH:25][CH:26]=3)[CH2:17][CH2:16]2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 126497945-Chloro-1-(4-fluorophenyl)-1-oxopentaneHCID 22048836N-[3-(4-Piperidinyl)phenyl]propanamide

Product 1

HCID 22049279N-(3-{1-[5-(4-Fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)propanamide

Procedure

Prepared by Procedure K and Scheme B1 using 5-chloro-1-(4-fluorophenyl)-1-pentanone and N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 411.2 (M+H)+.

Workup

  1. customPrepared by Procedure K and Scheme B1

Sources & evidence

ORD record
ord-497e202d80794c2aa33d83fb5c7ea1de
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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