1-Propanesulfonyl chloride → HCID 58651299, compound

HRID 1832766Notes

Reaction equation

HRID 1832766 reaction equation
[CH2:1]([S:4](Cl)(=[O:6])=[O:5])[CH2:2][CH3:3].[NH2:8][C@H:9]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:19]=[C:20]([NH:24][C:25](=[O:29])[CH:26]([CH3:28])[CH3:27])[CH:21]=[CH:22][CH:23]=2)[CH2:14][CH2:13]1>>[CH3:27][CH:26]([CH3:28])[C:25]([NH:24][C:20]1[CH:21]=[CH:22][CH:23]=[C:18]([CH:15]2[CH2:14][CH2:13][N:12]([CH2:11][CH2:10][C@@H:9]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)[NH:8][S:4]([CH2:1][CH2:2][CH3:3])(=[O:6])=[O:5])[CH2:17][CH2:16]2)[CH:19]=1)=[O:29]

Participants

3

Reactant 2

HCID 662791-Propanesulfonyl chlorideHCID 69523474N-(3-(1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl)phenyl)-2-methylpropanamide

Product 1

HCID 58651299HCID 58651299, compound

Procedure

Prepared by Procedure Q1 and Scheme AC using 1-propanesulfonyl chloride and N-(3-{1-[(3S)-3-amino-3-phenylpropyl]-4-piperidinyl}phenyl)-2-methylpropanamide: ESMS m/e: 486.2 (M+H)+.

Workup

  1. customPrepared by Procedure Q1 and Scheme AC

Sources & evidence

ORD record
ord-d4b5720a0b4045b2bf3d0d98a688f9e4
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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