2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester → HCID 22049109, compound

HRID 1832769Notes

Reaction equation

HRID 1832769 reaction equation
Cl[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3].[NH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:25]=[C:26]([NH:30][C:31](=[O:35])[CH:32]([CH3:34])[CH3:33])[CH:27]=[CH:28][CH:29]=2)[CH2:20][CH2:19]1>>[C:31]([NH:30][C:26]1[CH:25]=[C:24]([CH:21]2[CH2:22][CH2:23][N:18]([CH2:17][CH2:16][CH2:15][NH:14][S:2]([C:5]3[CH:9]=[CH:8][S:7][C:6]=3[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3])[CH2:19][CH2:20]2)[CH:29]=[CH:28][CH:27]=1)(=[O:35])[CH:32]([CH3:34])[CH3:33]

Participants

3

Reactant 2

HCID 27367332-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl esterHCID 16757470N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}2-methylpropanamide

Product 1

HCID 22049109HCID 22049109, compound

Procedure

Prepared Procedure Q1 and Scheme AC using methyl 3-(chlorosulfonyl)-2-thiophenecarboxylate and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide: Anal. Calcd for C24H33N3O5S.HCl: C, 6.00; H, 5.30; N, 7.72. Found: C, 52.9; H, 6.04; N, 7.59; ESMS m/e: 508.2 (M+H)+.

Workup

  1. customPrepared Procedure Q1 and Scheme AC

Sources & evidence

ORD record
ord-521d720b81f742758c886d2ee53358d6
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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