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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1832787Generated: October 26, 2026

1-(4-Nitrophenyl)-5-(trifluoromethyl)pyrazole-4-carbonyl chloride → N-(6-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}hexyl)-1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

https://huagongshe.com/reaction/1832787

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Nitrophenyl)-5-(trifluoromethyl)pyrazole-4-carbonyl chlorideHCID 2775746—
ReactantN-{3-[1-(6-Aminohexyl)4-piperidinyl]phenyl}-2-methylpropanamideHCID 16755868—
SolventTetrahydrofuranHCID 8028—
ProductN-(6-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}hexyl)-1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamideHCID 22049026—

Reaction Steps

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(6-aminohexyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride: ESMS m/e: 629.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07067534B1
Source datasetuspto-grants-2006_06
ORD IDord-27c527cf34084fbe86a100372b491f23
Source noteuspto-grants-2006_06