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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1832803Generated: November 1, 2026

2-(4-Chlorophenoxy)pyridine-3-carbonyl chloride → 2-(4-Chlorophenoxy)-N-(3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}propyl)nicotinamide

https://huagongshe.com/reaction/1832803

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Chlorophenoxy)pyridine-3-carbonyl chlorideHCID 2774898—
ReactantN-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}2-methylpropanamideHCID 16757470—
SolventTetrahydrofuranHCID 8028—
Product2-(4-Chlorophenoxy)-N-(3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}propyl)nicotinamideHCID 22048915—

Reaction Steps

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 2-(4-chlorophenoxy)nicotinoyl chloride: ESMS m/e: 535.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07067534B1
Source datasetuspto-grants-2006_06
ORD IDord-4083053f62fd4f5c896d858967ad5adf
Source noteuspto-grants-2006_06