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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1832840Generated: October 30, 2026

2-(4-Chlorophenoxy)pyridine-3-carbonyl chloride → 2-(4-Chlorophenoxy)-N-(4-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}butyl)nicotinamide

https://huagongshe.com/reaction/1832840

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Chlorophenoxy)pyridine-3-carbonyl chlorideHCID 2774898—
ReactantN-{3-[1-(4-Aminobutyl)4-piperidinyl]phenyl}-2-methylpropanamideHCID 16757471—
SolventTetrahydrofurane dichloromethaneHCID 21919333—
Product2-(4-Chlorophenoxy)-N-(4-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}butyl)nicotinamideHCID 22049433—

Reaction Steps

Prepared by Procedure Q2 (THF/DCM, 1:3) and Scheme AT using N-{3-[1-(4-aminobutyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 2-(4-chlorophenoxy)nicotinoyl chloride: ESMS m/e: 549.0 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07067534B1
Source datasetuspto-grants-2006_06
ORD IDord-dcfb9a7af8804a9e84e2e9ecb12f6e8d
Source noteuspto-grants-2006_06