N-methyl-N-phenyl-hydrazine → 2-Methyl-N-{3-[1-(3-{1-methyl-2-[4-(trifluoromethyl)phenyl]-1H-indol-3-YL}propyl)-4-piperidinyl]phenyl}propanamide

HRID 1832844Notes

Reaction equation

HRID 1832844 reaction equation
[CH3:1][CH:2]([CH3:34])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22](=O)[C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4].[CH3:35][N:36]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)N>>[CH3:1][CH:2]([CH3:34])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][C:21]3[C:43]4[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=4)[N:36]([CH3:35])[C:22]=3[C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4]

Participants

3

Reactant 2

HCID 36299N-methyl-N-phenyl-hydrazineHCID 220492072-Methyl-N-[3-(1-(5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl}-4-piperidinyl)phenyl]propanamide

Product 1

HCID 220495422-Methyl-N-{3-[1-(3-{1-methyl-2-[4-(trifluoromethyl)phenyl]-1H-indol-3-YL}propyl)-4-piperidinyl]phenyl}propanamide

Procedure

Prepared by Procedure E and Scheme M using 2-methyl-N-[3-(1-{5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl}-4-piperidinyl)phenyl]propanamide and 1-methyl-1-phenylhydrazine: ESMS m/e: 562.2 (M+H)+.

Workup

  1. customPrepared by Procedure E and Scheme M

Sources & evidence

ORD record
ord-81fdd212d17a450bad8b6b82cf17e8bd
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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