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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1832856Generated: October 30, 2026

4-(Trifluoromethoxy)phenylhydrazine hydrochloride → N-[3-(1-{3-[2-(2-Fluorophenyl)-5-(trifluoromethoxy)-1H-indol-3-YL]propyl}-4-piperidinyl)phenyl]-2-methylpropanamide

https://huagongshe.com/reaction/1832856

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethoxy)phenylhydrazine hydrochlorideHCID 2777328—
ReactantN-(3-{1-(5-(2-fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamideHCID 22049199—
ProductN-[3-(1-{3-[2-(2-Fluorophenyl)-5-(trifluoromethoxy)-1H-indol-3-YL]propyl}-4-piperidinyl)phenyl]-2-methylpropanamideHCID 22049119—

Reaction Steps

Prepared by Procedure E and Scheme M using N-(3-{1-[5-(2-fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 4-(trifluoromethoxy)phenylhydrazine hydrochloride: ESMS m/e: 582.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07067534B1
Source datasetuspto-grants-2006_06
ORD IDord-4117d07f7a384eda8def203ea5050e05
Source noteuspto-grants-2006_06