4-Methylphenylhydrazine monohydrochloride → 2-Methyl-N-[3-(1-{3-[5-methyl-2-(4-nitrophenyl)-1H-indol-3-YL]propyl}-4-piperidinyl)phenyl]propanamide

HRID 1832937Notes

Reaction equation

HRID 1832937 reaction equation
[CH3:1][CH:2]([CH3:33])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]([C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][CH:25]=3)=O)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4].Cl.[CH3:35][C:36]1[CH:41]=[CH:40][C:39]([NH:42]N)=[CH:38][CH:37]=1>>[CH3:1][CH:2]([CH3:33])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][C:21]3[C:40]4[C:39](=[CH:38][CH:37]=[C:36]([CH3:35])[CH:41]=4)[NH:42][C:22]=3[C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][CH:25]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4]

Participants

3

Reactant 2

HCID 125044-Methylphenylhydrazine monohydrochlorideHCID 220488632-Methyl-N-(3-{1-[5-(4-nitrophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)propanamide

Product 1

HCID 220490242-Methyl-N-[3-(1-{3-[5-methyl-2-(4-nitrophenyl)-1H-indol-3-YL]propyl}-4-piperidinyl)phenyl]propanamide

Procedure

Prepared by Procedure E and Scheme M using 2-methyl-N-(3-{1-[5-(4-nitrophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)propanamide and 4-methylphenylhydrazine hydrochloride: ESMS m/e: 539.1 (M+H)+.

Workup

  1. customPrepared by Procedure E and Scheme M

Sources & evidence

ORD record
ord-8f3ed0cd8d074d8192c1d443dd53cb0e
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

Loading…