Acetic Anhydride → HCID 86752228, compound

HRID 1833Notes

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)/[CH:7]=[CH:8]\[C:9]1[CH:13]=[CH:12][S:11][C:10]=1[C:14]([O:16][CH3:17])=[O:15])([O-])=O.[C:21](OC(=O)C)(=[O:23])[CH3:22]>>[C:21]([NH:1][C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)/[CH:7]=[CH:8]\[C:9]1[CH:13]=[CH:12][S:11][C:10]=1[C:14]([O:16][CH3:17])=[O:15])(=[O:23])[CH3:22]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 86752229HCID 86752229, compound

Product 1

HCID 86752228HCID 86752228, compoundYield 91.3%

Procedure

Substantially the same procedure as in Reference Example 14 was repeated using methyl (Z)-3-(3-nitrostyryl)-2-thiophenecarboxylate obtained in Reference Example 13 (3.51 g, 12.1 mmol), and also using acetic anhydride (3.43 ml, 36.3 mmol) instead of trimethylacetyl chloride, to give methyl (Z)-3-(3-acetamidostyryl)-2-thiophenecarboxylate (3.33 g, 2 steps, 91.3%).

Sources & evidence

ORD record: ord-61670ca8f3ee46f6b6f8d3342a1692cf
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05726325

Reaction notes

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