4-Iodo-1,2-dimethylbenzene → N-[3-(1-{[1-(3,4-Dimethylphenyl)-1H-indol-4-YL]methyl}-4-piperidinyl)phenyl]-2-methylpropanamide
Reaction equation
[NH:1]1[C:9]2[C:4](=[C:5]([CH2:10][N:11]3[CH2:16][CH2:15][CH:14]([C:17]4[CH:18]=[C:19]([NH:23][C:24](=[O:28])[CH:25]([CH3:27])[CH3:26])[CH:20]=[CH:21][CH:22]=4)[CH2:13][CH2:12]3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.I[C:30]1[CH:35]=[CH:34][C:33]([CH3:36])=[C:32]([CH3:37])[CH:31]=1>>[CH3:37][C:32]1[CH:31]=[C:30]([N:1]2[C:9]3[C:4](=[C:5]([CH2:10][N:11]4[CH2:16][CH2:15][CH:14]([C:17]5[CH:18]=[C:19]([NH:23][C:24](=[O:28])[CH:25]([CH3:26])[CH3:27])[CH:20]=[CH:21][CH:22]=5)[CH2:13][CH2:12]4)[CH:6]=[CH:7][CH:8]=3)[CH:3]=[CH:2]2)[CH:35]=[CH:34][C:33]=1[CH3:36]Participants
3
Procedure
Prepared by Procedure C and Scheme Q1, with CuBr in place of Cu, using N-{3-[1-(1H-indol-4-ylmethyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 4-iodo-1,2-dimethylbenzene: ESMS m/e: 480.0 (M+H)+.
Sources & evidence
- ORD record
- ord-0cbee9c6488549b3968be8f120c14cc2
- Source dataset
- uspto-grants-2006_06
- Patent number
- US07067534B1
Reaction notes
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