2-methyl-N-[3-(4-piperidyl)phenyl]propanamide → N-(3-{1-[5-(3-Fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 1833030Notes

Reaction equation

HRID 1833030 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[CH:9]=1)=[O:7].[CH3:15][CH:16]([CH3:32])[C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:21]=1)=[O:18]>>[F:14][C:10]1[CH:9]=[C:8]([C:6](=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2][N:29]2[CH2:30][CH2:31][CH:26]([C:22]3[CH:21]=[C:20]([NH:19][C:17](=[O:18])[CH:16]([CH3:15])[CH3:32])[CH:25]=[CH:24][CH:23]=3)[CH2:27][CH2:28]2)[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamideHCID 220491125-Chloro-1-(3-fluorophenyl)-1-oxopentane

Product 1

HCID 22049351N-(3-{1-[5-(3-Fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure K and Scheme E using 5-chloro-1-(3-fluorophenyl)-1-pentanone and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 425.2 (M+H)+.

Workup

  1. customPrepared by Procedure K and Scheme E

Sources & evidence

ORD record
ord-1638bb7eb86a49a29c4947bf9ea2cfe2
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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