3,4-Dimethoxyphenol → N-(3-{1-[6-(3,4-Dimethoxyphenoxy)-6-(2-fluorophenyl)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 1833047Notes

Reaction equation

HRID 1833047 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:11])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH:19](O)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][CH:28]([C:31]2[CH:32]=[C:33]([NH:37][C:38](=[O:42])[CH:39]([CH3:41])[CH3:40])[CH:34]=[CH:35][CH:36]=2)[CH2:27][CH2:26]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[O:11][CH:19]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[F:12])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][N:25]1[CH2:26][CH2:27][CH:28]([C:31]2[CH:32]=[C:33]([NH:37][C:38](=[O:42])[CH:39]([CH3:41])[CH3:40])[CH:34]=[CH:35][CH:36]=2)[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 162513,4-DimethoxyphenolHCID 22048705N-(3-(1-[6-(2-fluorophenyl)-6-hydroxyhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Product 1

HCID 22049389N-(3-{1-[6-(3,4-Dimethoxyphenoxy)-6-(2-fluorophenyl)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure A and Scheme AN using 3,4-dimethoxyphenol and N-(3-{1-[6-(2-fluorophenyl)-6-hydroxyhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide: ESMS m/e: 577.6 (M+H)+.

Sources & evidence

ORD record
ord-a81c507e9da844c28b63b95184c1b03e
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

Loading…