Hydrochloric Acid → N-(3-{1-[6-(4-Fluorophenoxy)-6-(4-fluorophenyl)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Participants

Reaction Steps

Prepared by Procedure A and Scheme AN using 4-fluorophenol and N-(3-{1-[6-(4-fluorophenyl)-6-hydroxyhexyl]-4-piperidinyl}phenyl)-2-methylpropanamide: 1H NMR (400 MHz, CDCl3), HCl salt δ 8.22 (s, br, 1H), 7.74–6.70 (m, 12H) 5.05–4.94 (m, 1H), 3.66–3.52 (m, br, 2H), 3.02–2.83 (m, br, 2H), 2.81–2.58 (m, br, 4H), 2.58–2.36 (m, br, 2H), 2.02–1.66 (m, br, 6H), 1.66–1.46 (m, br, 1H), 1.46–1.35 (m, br, 3H), 1.26 (d, 6H, J=6.0 Hz); ESMS m/e: 535.1 (M+H)+.

Provenance & Evidence