2-Fluoro-5-(trifluoromethyl)phenol → N-[3-(1-{6-[2-Fluoro-5-(trifluoromethyl)phenoxy]-6-phenylhexyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 1833069Notes

Reaction equation

HRID 1833069 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[OH:12].O[CH:14]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH:23]([C:26]2[CH:27]=[C:28]([NH:32][C:33](=[O:37])[CH:34]([CH3:36])[CH3:35])[CH:29]=[CH:30][CH:31]=2)[CH2:22][CH2:21]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:10])([F:11])[F:9])=[CH:4][C:3]=1[O:12][CH:14]([C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH:23]([C:26]2[CH:27]=[C:28]([NH:32][C:33](=[O:37])[CH:34]([CH3:36])[CH3:35])[CH:29]=[CH:30][CH:31]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 5188882-Fluoro-5-(trifluoromethyl)phenolHCID 22049151N-(3-[1-(6-hydroxy-6-phenylhexyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Product 1

HCID 22048865N-[3-(1-{6-[2-Fluoro-5-(trifluoromethyl)phenoxy]-6-phenylhexyl}-4-piperidinyl)phenyl]-2-methylpropanamide

Procedure

Prepared by Procedure A and Scheme AN using 2-fluoro-5-(trifluoromethyl)phenol and N-{3-[1-(6-hydroxy-6-phenylhexyl)-4-piperidinyl]phenyl}-2-methylpropanamide: ESMS m/e: 585.3 (M+H)+.

Sources & evidence

ORD record
ord-11f61dbd1ad341dc9e95485509ce32fe
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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