Hydrochloric Acid → N-[3-(1-{5-(3-Fluorophenyl)-5-[2-fluoro-5-(trifluoromethyl)phenoxy]pentyl}-4-piperidinyl)phenyl]-2-methylpropanamide

Participants

Reaction Steps

Prepared by Procedure A and Scheme AN using 2-fluoro-5-(trifluoromethyl)phenol and N-(3-{1-[5-(3-fluorophenyl)-5-hydroxypentyl)-4-piperidinyl}phenyl)-2-methylpropanamide: 1H NMR (400 MHz, CDCl3), HCl salt δ7.79 (s, br, 1H), 7.63–6.82 (m, 11H), 5.24–5.15 (m, 1H), 3.70–3.56 (br, 2H), 3.04–2.84 (br, 2H), 2.82–2.60 (m, br, 4H), 2.60–2.42 (m, br, 2H), 2.20–1.83 (m, br, 6H), 1.70–1.44 (m, br, 2H), 1.25 (d, 6H, J=6.4 Hz); ESMS m/e: 589.3 (M+H)+.

Provenance & Evidence