Lithium Hydroxide → HCID 11350419, compound

Participants

Reaction Steps

To a solution of 1-(3-carboxymethoxybenzoyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid ethyl ester (89 mg, 0.19 mmol) in 5 ml of methanol was added lithium hydroxide solution (0.5 N, 1.0 ml). The mixture was stirred at room temperature overnight. The reaction mixture was loaded to a preparative HPLC for purification to give 1-(3-Carboxymethoxy-benzoyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid as a fluffy solid (72.6 mg, 92%). ES-MS calcd for C21H17NO8 (m/e) 411.4, obsd 412.3 (M+H).

Provenance & Evidence