Selenium Dioxide → HCID 22048267, compound

Participants

Reaction Steps

The above 1-(3-methoxybenzyl)-4-cyanomethyl-6,7-dimethoxyisoquinoline (152.7 mg, 0.438 mmol) was dissolved in 10 ml of ethyl acetate, then selenium dioxide (48.8 mg, 58.8 mg, 0.529 mmol) was added. The mixture was refluxed for 1 hr. The crude mixture was filtered through a thin layer of silica gel and washed with ethyl acetate. After the evaporation of solvents, the residue was purified through a flash column chromatography using ethyl acetate and hexane (2/1) to give 1-(3-methoxybenzoyl)-4-cyanomethyl-6,7-dimethoxyisoquinoline as a solid (68 mg, 42.8%).

Provenance & Evidence