Triethylamine → HCID 11487017, compound

Participants

Reaction Conditions

Reaction Steps

The above carboxylic acid (70.3 mg) was dissolved in 6 ml of THF. Then at −30° C., triethylamine (0.055 ml) was added followed by isobutyl chloroformate (0.034 ml). The mixture was stirred at −20° C. for 30 minutes. Then 30% ammonia hydroxide solution (0.15 ml) was added. The mixture was stirred at room temperature overnight and then purified through a reverse preparative HPLC to give 3-[1-(3-Isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-propionamid as a fluffy solid (47.2 mg). ES-MS calcd for C24H26N2O5 (m/e) 422.5, obsd 423.4 (M+H).

Provenance & Evidence