HCID 11211973, compound → HCID 22048387, compound

HRID 1833121Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC1C=C(C=CC=1)C(C1C2C(=CC(OC)=C(OC)C=2)C(CC(O)=O)=CN=1)=O)(C)C.[CH:38]([O:41][C:42]1[CH:43]=[C:44]([CH:65]=[CH:66][CH:67]=1)[C:45]([C:47]1[C:56]2[C:51](=[CH:52][C:53]([O:59][CH3:60])=[C:54]([O:57][CH3:58])[CH:55]=2)[C:50]([CH2:61][C:62]([NH2:64])=[O:63])=[CH:49][N:48]=1)=[O:46])([CH3:40])[CH3:39]>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:38]([O:41][C:42]1[CH:43]=[C:44]([CH:65]=[CH:66][CH:67]=1)[C:45]([C:47]1[C:56]2[C:51](=[CH:52][C:53]([O:59][CH3:60])=[C:54]([O:57][CH3:58])[CH:55]=2)[C:50]([CH2:61][C:62]([NH2:64])=[O:63])=[CH:49][N:48]=1)=[O:46])([CH3:40])[CH3:39]

Participants

Reactant 2

HCID 11211973HCID 11211973, compound

HCID 69666892HCID 69666892, compound

Product 1

HCID 22048387HCID 22048387, compound

Procedure

This compound was obtained during the last step preparative HPLC purification in the preparation of [1-(3-Isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetic acid (Example 24). One of the two fractions with the earlier retention time was identified as 2-[1-(3-Isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide (114 mg). ES-MS calcd for C23H24N2O5 (m/e) 408.46, obsd 409.4 (M+H).

Sources & evidence

ORD record: ord-ebdf25412e0347f8a012ad92be2c38e9
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067529B2

Reaction notes

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