Acetic Anhydride → 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester

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Reaction Steps

To a stirred solution of 6-(3-hydroxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1H isoquinoline-2-carboxylic acid ethyl ester (130 mg, 0.30 mmol) in pyridine (2 μL) was added acetic anhydride (1 mL). The reaction mixture was stirred at room temperature for 15 hrs. The solvent was evaporated and toluene was added to remove pyridine completely. The crude product 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester (142, 99% yield) was used without further purification.

Provenance & Evidence