Potassium Carbonate → HCID 69551692, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 6-hydroxy-1-(3-isopropoxy-benzoyl)-7-methoxy-isoquinoline-4-carboxylic acid ethyl ester (30 mg, 0.073 mmol) in N,N-dimethylformamide (1 mL) was added potassium carbonate (81.1 mg, 0.58 mmol) and 3-bromo-1-propanol (0.033 mL, 0.22 mmol) at room temperature. The reaction mixture was heated 85° C. for 2 hrs. The solvent was evaporated and the residue was purified on a flash chromatography (Merck Silica gel 60, 70–230 mesh, 50% ethyl acetate/hexane) to afford product 6-(3-hydroxy-propoxy)-1-(3-isopropoxy-benzoyl)-7-methoxy-isoquinoline-4-carboxylic acid ethyl ester as a colorless oil (34 mg, 99% yield).

Provenance & Evidence