Potassium Carbonate → HCID 69558865, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 6-hydroxy-7-methoxy-1-(3-ethoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester (737 mg, 1.92 mmol) in N,N-dimethylformamide (10 mL) was added potassium carbonate (2.6 g, 19.2 mmol) and 3-bromo-1-propanol (0.868 m]L, 9.62 mmol) at room temperature. The reaction mixture was heated 85° C. for 2 hrs. The solvent was evaporated and the residue was purified on a flash chromatography (Merck Silica gel 60, 70–230 mesh, 50% ethyl acetate/hexane) to afford product 6-(3-hydroxy-propoxy)-7-methoxy-1-(3-ethoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester as a colorless oil (260 mg, 31% yield).

Provenance & Evidence