Acetic Anhydride → HCID 69558102, compound

Participants

Reaction Steps

To a stirred solution of 6-(3-hydroxy-propoxy)-7-methoxy-1-(3-ethoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester (160 mg, 0.59 mmol) in pyridine (4.2 mL) was added acetic anhydride (2.1 mL). The reaction mixture was stirred at room temperature for 15 hrs. The mixture was concentrated in vacuo to afford 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-ethoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester (285 mg, 99% yield). The crude product was used without further purification.

Provenance & Evidence