HCID 22048326, compound → HCID 22048336, compound

Participants

Reaction Steps

To a stirred solution of 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-ethoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde (120 mg, 0.27 mmol) in chloroform (3 mL) was addend manganese (IV) oxide (279 mg, 2.7 mmol). The reaction mixture was stirred at room temperature for 15 hrs, filtered through a celite pad®, and washed with chloroform. The filtrate was concentrated in vacuo to afford 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-ethoxy-benzyl)-isoquinoline-4-carbaldehyde (120 mg, 99% yield). The crude product was used without further purification.

Provenance & Evidence