Potassium Carbonate → HCID 22048412, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution 6-(3-bromo-propoxy)-1-(3-ethoxy-benzoyl)-7-methoxy-isoquinoline-4-carbaldehyde (62 g, 0.13 mmol) in N,N-dimethylformamide (2 mL) was added potassium carbonate (181 mg, 1.30 mmol) and pyrrolidine (0.032 mL, 0.66 mmol) at room temperature. The reaction mixture was heated 85° C. for 2 hrs. The mixture was diluted with ethyl acetate and water. The aqueous phase was extracted with ethyl acetate (3×30 mL). The combined extracts were washed with saturated aqueous sodium chloride (50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to afford product 6-(3-pyrrolidin-1-yl-propoxy)-7-methoxy-1-(3-ethoxy-benzoyl)-isoquinoline-4-carbaldehyde as a colorless oil (63 mg, 99% yield).

Provenance & Evidence