2-Bromoethanol → HCID 22048428, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 6-hydroxy-7-methoxy-1-(3-ethoxy-benzyl)-isoquinoline-4-carbaldehyde (90 mg, 0.255 mmol) in N,N-dimethylformamide (2 mL) was added potassium carbonate (234 mg, 2.55 mmol) and 2-bromoethanol (0.090 mL, 1.27 mmol) at room temperature. The reaction mixture was heated 85° C. for 2 hrs. The solvent was evaporated and the residue was purified on a flash chromatography (Merck Silica gel 60, 70–230 mesh, 50% ethyl acetate/hexane) to afford product 1-(3-ethoxy-benzyl)-6-(2-hydroxy-ethoxy)-7-methoxy-isoquinoline-4-carbaldehyde as a colorless oil (50 mg, 52% yield).

Provenance & Evidence