Sulfuric Acid → [2-Cyano-2-(3,4-dimethoxy-phenyl)-vinyl]-carbamic acid ethyl ester

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-(3,4-dimethoxy-phenyl)-3-oxo-propionitrile (26 g, 127 mmol) in toluene ((275 mL) was added ethyl carbamate (11.3 g, 127 mmol) and concentrated sulfuric acid solution (2.0 mL). The reaction mixture was heated at 1110° C. with a Dean-Stark apparatus. The mixture was cooled and a solid was precipitated. The mixture was filtered and the solid was collected. The yellow solid was washed with diethyl ether to afford [2-cyano-2-(3,4-dimethoxy-phenyl)-vinyl]-carbamic acid ethyl ester (20 g, 57% yield).

Provenance & Evidence