Acetyl chloride → Methyl 3-Hydroxyphenylacetate

Participants

Reaction Steps

To methanol (300 mL) was added acetyl chloride (8.9 mL) dropwise in 10 minutes with stirring. 3-Hydroxyphenylacetic acid (25 g, 164 mmol) was added to the mixture at one time. The reaction mixture was stirred at room temperature for 15 hrs. The solvent was evaporated and the residue was concentrated in vacuo to afford 3-hydroxyphenyl acetic acid methyl ester (27.3 g, 99% yield) as a red oil.

Provenance & Evidence