Selenium Dioxide → HCID 22048437, compound

Participants

Reaction Steps

A solution of 1-(3-isopropoxy-benzyl)-6,7-dimethoxy-isoquinoline-4-carbaldehyde (200 mg, 0.547 mmol) and selenium dioxide (121 mg, 1.09 mmol) in ethyl acetate was refluxed for 45 min. The mixture was cooled and filtered through celite. The celite was washed well with ethyl acetate and the combined filtrates were concentrated in vacuo to afford 1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinoline-4-carbaldehyde (160 mg, 77%) as a light yellow solid that was used without further purification: APCI-MS (M+H+) m/e 380; 1H NMR (300 MHz) compatible.

Provenance & Evidence