HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetamidine monohydrochloride → Diethyl 1-amino-1-methylmethyleneaminocarbonylphosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetamidine monohydrochloride | HCID 67170 | — |
| Reactant | Phosphinecarboxylic acid, 1,1-diethoxy-, methyl ester, 1-oxide | HCID 170573 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Diethyl 1-amino-1-methylmethyleneaminocarbonylphosphonate | HCID 54283790 | — |
Reaction Steps
A solution of 98 parts of diethyl methoxycarbonylphosphonate plus 47 parts of acetamidine hydrochloride in 1000 parts of anhydrous tetrahydrofuran can be refluxed for 8 hours and the solvent then removed under reduced pressure to give diethyl 1-amino-1-methylmethyleneaminocarbonylphosphonate. In a similar manner, starting with the appropriate alkoxycarbonylphosphonate and imino compounds, the following compounds can be prepared:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04066434 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-86fc9fb571a944cbafec8910d46961a9 |
| Source note | uspto-grants-1978_01 |