Methanol → HCID 21388924, compound

Participants

Reaction Steps

In a 4-necked flask, equipped with stirrer, reflux cooler, thermometer and drip funnel, a solution of 110.8 g (0.6 mole) of p-chloromethylbenzoic acid methyl ester in 150 ml of hexamethylphosphoric triamide is added dropwise, with stirring, at 25° C to a solution (prepared at 5°-10° C) of 38.4 g (0.3 mole) of 2,2-dimethylimidazolidine-4,5-dione and 32.4 g (0.6 mole) of sodium methylate in 225 ml of anhydrous methanol and 225 ml of hexamethylphosphoric triamide.

Provenance & Evidence