反应详情

2.3 g. of 8-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one of Example 1b are refluxed with 1 g. of zinc chloride in 20 ml. of acetic acid for 100 hours. The mixture is cooled to room temperature, diluted with 10 ml. of water and the precipitated 8-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin5(4H)-one is filtered off, yield: 1.7 g. (81%); m.p. > 300° (DMF).

1. additiondiluted with 10 ml
2. filtrationof water and the precipitated 8-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin5(4H)-one is filtered off