Acetic Acid → HCID 178422362, compound

HRID 1833341Notes

Reaction equation

HRID 1833341 reaction equation
Cl[C:2]1[N:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[N:9]([N:10]=[C:11]([CH3:13])[CH:12]=3)[C:4]=2[CH:3]=1.C(O)(=[O:19])C>[Cl-].[Zn+2].[Cl-]>[OH:19][C:2]1[N:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[N:9]([N:10]=[C:11]([CH3:13])[CH:12]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 1360252228-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one

Product 1

HCID 178422362HCID 178422362, compound

Reagents, catalysts & solvents 1

HCID 3007855ZincchlorideCatalyst

Procedure

2.3 g. of 8-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one of Example 1b are refluxed with 1 g. of zinc chloride in 20 ml. of acetic acid for 100 hours. The mixture is cooled to room temperature, diluted with 10 ml. of water and the precipitated 8-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin5(4H)-one is filtered off, yield: 1.7 g. (81%); m.p. > 300° (DMF).

Workup

  1. additiondiluted with 10 ml
  2. filtrationof water and the precipitated 8-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin5(4H)-one is filtered off

Sources & evidence

ORD record
ord-4bd906c3ac9b4dec877df6d0367c22eb
Source dataset
uspto-grants-1978_01
Patent number
US04066645

Reaction notes

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