Butylamine → N-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine

HRID 1833346Notes

Reaction equation

HRID 1833346 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1.[CH2:16]([NH2:20])[CH2:17][CH2:18][CH3:19]>>[CH2:16]([NH:20][C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1)[CH2:17][CH2:18][CH3:19]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 213891855-Chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine

Product 1

HCID 21389188N-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine

Procedure

2.2 g. of 5-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine of Example 18 are refluxed in 10 ml. of n-butylamine for 12 hours. The excess amine is evaporated and the residue treated with 10 ml. of water. N-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine is filtered off, yield: 2 g. (80%); m.p. 116.1° (methanol).

Workup

  1. customThe excess amine is evaporated
  2. additionthe residue treated with 10 ml
  3. filtrationN-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine is filtered off

Sources & evidence

ORD record
ord-ac054abd91924b8ea2013aa473bbef05
Source dataset
uspto-grants-1978_01
Patent number
US04066645

Reaction notes

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