Diphenyl Ether → HCID 178469574, compound

Participants

Reaction Steps

33.2 g. of [[(2,5-dimethylpyrazolo[1,5-a]pyrimidin7-yl)amino]methylene]propanedioic acid, ethyl ester (0.1 mol.) are heated in 100 ml. of diphenyl ether at 240° for 7 minutes. The mixture is cooled rapidly and 100 ml. of diethyl ether are added. The product, 6-hydroxy-2,5-dimethylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-7-carboxylic acid, ethyl ester, precipitates and is filtered off, yield 20.1 g. (75%), m.p. 207°-208° (methanol).

Provenance & Evidence