Sec-Butylamine → HCID 131711013, compound

HRID 1833351Notes

Reaction equation

HRID 1833351 reaction equation
Cl[C:2]1[C:7]2[C:8]([CH3:16])=[N:9][C:10]3[N:11]([N:12]=[C:13]([CH3:15])[CH:14]=3)[C:6]=2[N:5]=[CH:4][C:3]=1[C:17]([O:19][CH2:20][CH3:21])=[O:18].[CH:22]([NH2:26])([CH2:24][CH3:25])[CH3:23]>>[CH3:15][C:13]1[CH:14]=[C:10]2[N:9]=[C:8]([CH3:16])[C:7]3[C:2]([NH:26][CH:22]([CH3:23])[CH2:24][CH3:25])=[C:3]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:4]=[N:5][C:6]=3[N:11]2[N:12]=1

Participants

3

Reactant 2

HCID 24874Sec-ButylamineHCID 86735321HCID 86735321, compound

Product 1

HCID 131711013HCID 131711013, compound

Procedure

3.0 g. of 6-chloro-2,5-dimethylpyrazolo[1,5-a]-pyrido[3,2-e]pyrimidine-7-carboxylic acid, ethyl ester of Example 1c (0.01 mol.) are dissolved in 20 ml. of alcohol. 2.1 g. of sec. butylamine (0.03 mol.) are added and the mixture is refluxed with stirring for 1 hour. The solvent and excess amine is removed in vacuo and the crystalline residue is treated with water and filtered off to obtain 2,5-dimethyl-6-[(1-methylpropyl)-amino]pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-7-carboxylic acid, ethyl ester, yield 3.1 g. (91%), m.p. 113°-115° (ethyl acetate).

Workup

  1. temperaturethe mixture is refluxed
  2. customThe solvent and excess amine is removed in vacuo
  3. additionthe crystalline residue is treated with water
  4. filtrationfiltered off

Sources & evidence

ORD record
ord-3ae519bd97be4872a021acdd9cb00ddc
Source dataset
uspto-grants-1978_01
Patent number
US04066643

Reaction notes

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